Open AccessThe methyl donor S-adenosyl methionine reverses the DNA methylation signature of chronic neuropathic pain in mouse frontal cortex
Author(s) -
Lucas Topham,
Stéphanie Grégoire,
HyungMo Kang,
Mali SalmonDivon,
Elad Lax,
Magali Millecamps,
Moshe Szyf,
Laura S. Stone
Publication year - 2021
Publication title -
pain reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.113
H-Index - 15
ISSN - 2471-2531
DOI - 10.1097/pr9.0000000000000944
Subject(s) - neuropathic pain , chronic pain , epigenetics , dna methylation , prefrontal cortex , neuroscience , epigenome , neuroplasticity , medicine , biology , gene , gene expression , genetics , cognition
Supplemental Digital Content is Available in the Text. Chronic administration of S-adenosylmethionine reverses neuropathic pain–induced changes in DNA methylation in the mouse frontal cortex.