Open AccessAutoimmune regulation of chronic pain
Author(s) -
Michael J. Lacagnina,
Cobi J. Heijnen,
Linda R. Watkins,
Peter M. Grace
Publication year - 2021
Publication title -
pain reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.113
H-Index - 15
ISSN - 2471-2531
DOI - 10.1097/pr9.0000000000000905
Subject(s) - autoantibody , autoimmunity , immunology , nociceptor , chronic pain , medicine , neuroscience , immune system , sensitization , receptor , rheumatoid arthritis , autoimmune disease , signal transduction , complement system , antibody , nociception , biology , microbiology and biotechnology
Autoantibodies can contribute to peripheral and central sensitization through activation of complement pathway, activation of neuronal Fc gamma receptors, and disrupted function of neuronal ion channels.