Open AccessEffects of inflammatory pain on CB1 receptor in the midbrain periaqueductal gray
Author(s) -
Adrianne R. Wilson-Poe,
Beth M Wiese,
Cherkaouia Kibaly,
Lindsay M. Lueptow,
Jeniffer J. Garcia,
Preeti Anand,
Catherine M. Cahill,
José A. Morón
Publication year - 2021
Publication title -
pain reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.113
H-Index - 15
ISSN - 2471-2531
DOI - 10.1097/pr9.0000000000000897
Subject(s) - periaqueductal gray , cannabinoid receptor , analgesic , nociception , pharmacology , receptor , cannabinoid , downregulation and upregulation , medicine , neuroscience , neuropathic pain , midbrain , endocrinology , central nervous system , psychology , chemistry , agonist , biochemistry , gene
Western blot and GTPγS analyses reveal inflammatory pain–induced adaptations in the midbrain periaqueductal gray, which is critically involved in descending pain modulation. Pain upregulates the expression of the CB1 receptor and increases G-protein coupling in the periaqueductal gray.