Open AccessRegular physical activity prevents development of chronic muscle pain through modulation of supraspinal opioid and serotonergic mechanisms
Author(s) -
Renan Guedes de Brito,
Lynn Rasmussen,
Kathleen A. Sluka
Publication year - 2017
Publication title -
pain reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.113
H-Index - 15
ISSN - 2471-2531
DOI - 10.1097/pr9.0000000000000618
Subject(s) - rostral ventromedial medulla , serotonergic , hyperalgesia , opioid , periaqueductal gray , (+) naloxone , medicine , nociception , serotonin , neuroscience , pharmacology , endocrinology , psychology , central nervous system , receptor , midbrain
The current study shows that blockade of opioid receptors systemically in the periaqueductal gray and the rostral ventromedial medulla prevents analgesia by 8 weeks of wheel running in a chronic muscle pain model. We further show increases in serotonin transporter expression and reversal of hyperalgesia with a selective reuptake inhibitor in the rostral ventromedial medulla in the chronic muscle pain model, and exercise normalizes serotonin transporter expression.