Open AccessClinical Targeting of Altered Metabolism in High-Grade Glioma
Author(s) -
Andrew J. Scott,
Costas A. Lyssiotis,
Daniel R. Wahl
Publication year - 2021
Publication title -
the cancer journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.825
H-Index - 89
eISSN - 1540-336X
pISSN - 1528-9117
DOI - 10.1097/ppo.0000000000000550
Subject(s) - glioma , medicine , clinical trial , brain cancer , bioinformatics , cancer , oncology , cancer research , biology
High-grade gliomas are among the deadliest of all cancers despite standard treatments, and new therapeutic strategies are needed to improve patient outcome. Targeting the altered metabolic state of tumors with traditional chemotherapeutic agents has a history of success, and our increased understanding of cellular metabolism in the past 2 decades has reinvigorated the concept of novel metabolic therapies in brain tumors. Here we highlight metabolic alterations in advanced gliomas and their translation into clinical trials using both novel agents and already established drugs repurposed for cancer treatment in an effort to improve outcome for these deadly diseases.