Open AccessObesity and Energy Balance Considerations in Triple-Negative Breast Cancer
Author(s) -
Elizabeth R. Berger,
Neil M. Iyengar
Publication year - 2021
Publication title -
the cancer journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.825
H-Index - 89
eISSN - 1540-336X
pISSN - 1528-9117
DOI - 10.1097/ppo.0000000000000502
Subject(s) - breast cancer , obesity , triple negative breast cancer , medicine , cancer , oncology , menopause , disease
Obesity is an increasingly prevalent state of energy imbalance that contributes to breast cancer risk and outcomes. The effects of obesity differ by breast cancer subtype and menopause. While most studies have focused on postmenopausal hormone receptor-positive disease, less is known about the relationship between obesity and triple-negative breast cancer (TNBC). Here we will review the observations linking obesity to TNBC, the socioeconomic disparities that contribute to obesity-related TNBC, and putative biologic mechanisms. Finally, we will consider the impact of obesity on surgical and medical treatment of TNBC and novel strategies to improve energy balance after cancer diagnosis.