Open AccessA Novel Ciliated, Mucin-producing Variant of HPV-related Cervical Adenosquamous Carcinoma In Situ: A Case Report
Author(s) -
Jin Xu,
Kay J. Park,
Paul Weisman
Publication year - 2020
Publication title -
international journal of gynecological pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 77
eISSN - 1538-7151
pISSN - 0277-1691
DOI - 10.1097/pgp.0000000000000714
Subject(s) - adenosquamous carcinoma , mucin , pathology , carcinoma in situ , in situ , cervical carcinoma , carcinoma , biology , medicine , adenocarcinoma , cervical cancer , chemistry , cancer , genetics , organic chemistry
Uterine cervical adenosquamous carcinoma in situ was originally defined as having either a uniform population of cells with features intermediate in appearance between glandular and squamous cells, or a mixture of distinct glandular and squamous components within a single lesion. The former type would likely be reclassified today as stratified mucin-producing intraepithelial lesion, while the latter type is vanishingly rare. Here, we report a novel case of bona fide adenosquamous carcinoma in situ, which exhibits 2 morphologically and immunophenotypically distinct components: (1) an inner glandular component composed of a single layer of p40-negative, ciliated, mucin-producing dysplastic columnar cells and (2) an outer p40-positive, stratified dysplastic squamous component otherwise identical to cervical intraepithelial neoplasia-3. Both components show block-positive staining for p16 and are positive for high-risk human papillomavirus RNA by in situ hybridization. Our finding expands the histological spectrum of human papillomavirus-associated preinvasive cervical lesions while also providing further evidence that human papillomavirus-driven processes can exhibit ciliated morphology.