Open AccessKetogenic Diet and Drug‐Induced Hepatotoxicity During Tuberculosis Treatment
Author(s) -
Branco Caetano Francisco,
Milheiro Silva Tiago,
Gonçalves Cristina,
Dias Ana Isabel,
Brito Maria João
Publication year - 2022
Publication title -
jpgn reports
Language(s) - English
Resource type - Journals
ISSN - 2691-171X
DOI - 10.1097/pg9.0000000000000216
Subject(s) - ketogenic diet , medicine , drug , liver injury , pathophysiology , pharmacology , tuberculosis , epilepsy , pathology , psychiatry
When therapy with hepatotoxic drugs is being considered, all other possible contributing agents of liver damage should be held to account. While not generally considered a risk factor, we present 2 cases in which ketogenic diet (KD) may have played a role in liver injury due to antituberculosis drugs. Ketogenic diet has been linked to liver injury, and while its pathophysiology remains obscure, carnitine depletion could play a role, as it is a mechanism of liver damage common to KD and antituberculosis drug regimens.