Open AccessInadvertent Acute Lipid Injectable Emulsion Overdose Resulting in Fat Overload Syndrome and Pancreatitis in a Patient with TPN Dependence
Author(s) -
Schlegelmilch Michael,
Feder Joshua,
Creery David
Publication year - 2022
Publication title -
jpgn reports
Language(s) - English
Resource type - Journals
ISSN - 2691-171X
DOI - 10.1097/pg9.0000000000000146
Subject(s) - medicine , acute pancreatitis , parenteral nutrition , pancreatitis , respiratory failure , intensive care unit , fat emulsion , lipid emulsion , intensive care medicine
We report a case of an acute, inadvertent, 7.5‐fold intravenous lipid emulsion overdose with 20% SMOFlipid in an 11‐month‐old female with tetratricopeptide repeat domain 7A (TTC7A) mutation, intestinal failure, and parenteral nutrition dependence. The overdose resulted in critical deterioration with evidence of fever, metabolic acidosis, respiratory failure, and pancreatitis that resulted in admission to the intensive care unit. This is a unique case of fat overload syndrome with acute pancreatitis following an accidental lipid injectable emulsion overdose in a pediatric patient.