Open AccessSevere Postnatal Cytomegalovirus Enterocolitis in Immunocompetent Term Infants Requiring Total Parenteral Nutrition
Author(s) -
HowardJones Annaleise R.,
CristernaTarrasa Giancarlo H.,
Khan Rabia,
Stormon Michael,
Arbuckle Susan,
Britton Philip N.
Publication year - 2021
Publication title -
jpgn reports
Language(s) - Uncategorized
Resource type - Journals
ISSN - 2691-171X
DOI - 10.1097/pg9.0000000000000110
Subject(s) - medicine , ganciclovir , cytomegalovirus , enterocolitis , necrotizing enterocolitis , parenteral nutrition , context (archaeology) , pediatrics , diarrhea , viremia , betaherpesvirinae , human cytomegalovirus , gastroenterology , intensive care medicine , herpesviridae , immunology , viral disease , virus , biology , paleontology
Postnatal cytomegalovirus enterocolitis is uncommon in immunocompetent infants. We report a 10‐week‐old term boy with severe and prolonged secretory diarrhea, leading to dependence on total parenteral nutrition and a 10‐week hospitalization. Cytomegalovirus enterocolitis was diagnosed based on duodenal biopsy in the context of marked viremia, and the child recovered promptly on initiation of ganciclovir. Collated case reports reveal delayed diagnoses as the norm but rapid improvement with antiviral treatment. Cytomegalovirus enterocolitis should be considered early as a differential diagnosis in infants with refractory diarrhea.