Open AccessAcute Liver Failure in a Healthy Young Female With COVID‐19
Author(s) -
Orandi Babak John,
Li Geling,
Dhall Deepti,
Bajpai Prachi,
Manne Upender,
Arora Nitin,
Lu Ailing,
Coronado Ana Carolina,
Kassel Rachel,
Pinninti Swetha,
Lewis Cora Elizabeth,
Chapleau Christopher,
Locke Jayme Elizabeth,
Gutierrez Sanchez Luz Helena
Publication year - 2021
Publication title -
jpgn reports
Language(s) - English
Resource type - Journals
ISSN - 2691-171X
DOI - 10.1097/pg9.0000000000000108
Subject(s) - medicine , covid-19 , liver injury , liver failure , coronavirus , liver biopsy , inflammation , pathological , respiratory failure , immune system , liver disease , immunology , disease , biopsy , pathology , infectious disease (medical specialty)
Several well‐described manifestations of infection with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) have been reported. Among them, a transient elevation of liver enzymes is the typical presentation of coronavirus disease 2019 (COVID‐19) liver‐related injury. The mechanism of liver involvement is likely a combination of viral injury and immune‐mediated inflammation. In contrast, acute liver failure in the setting of COVID‐19 has rarely been reported. Herein, we report a case of pediatric acute liver failure in a previously healthy female adolescent infected with SARS‐CoV‐2 with biopsy evidence of replicating virus in hepatocytes, which has not been previously reported.