Open AccessDisseminated and Central Nervous System Vaccine‐Strain Herpes Zoster Infection in a Teenager With Crohn's Disease on Maintenance Adalimumab Therapy
Author(s) -
D'Arienzo David,
Rumjahn Gryte Kailas,
Noya Francisco,
Morinville Veronique D.
Publication year - 2021
Publication title -
jpgn reports
Language(s) - English
Resource type - Journals
ISSN - 2691-171X
DOI - 10.1097/pg9.0000000000000072
Subject(s) - medicine , immunosuppression , adalimumab , disease , varicella vaccine , varicella zoster virus , complication , immunology , immunization , meningitis , inflammatory bowel disease , crohn's disease , dermatology , pediatrics , virus , immune system
Patients on immunosuppression, including inflammatory bowel disease patients on anti‐tumor necrosis factor therapies, are at increased risk of severe varicella and herpes zoster infections. Although varicella vaccine‐related herpes zoster reactivation is a rare complication, physicians must remain vigilant about this diagnosis, particularly in those on immunosuppressive medications. Here, we report a case of a patient with Crohn disease, on only adalimumab immunosuppression, who developed varicella vaccine‐related disseminated herpes zoster with meningitis, over 15 years after immunization.