Open AccessOutcomes of Infants With Severe Refractory Food Protein‐induced Allergic Proctocolitis Treated With Mesalamine
Author(s) -
Rojas Gallegos Maria Belen,
Crissinger Karen D.
Publication year - 2021
Publication title -
jpgn reports
Language(s) - English
Resource type - Journals
ISSN - 2691-171X
DOI - 10.1097/pg9.0000000000000024
Subject(s) - medicine , refractory (planetary science) , gastroenterology , food protein , reflux , disease , pediatrics , food science , chemistry , physics , astrobiology
This retrospective chart review evaluates the outcomes of mesalamine treatment in infants with severe food protein‐induced allergic proctocolitis (FPIAP) and persistent clinical symptoms despite the use of elemental formulas. Patients received mesalamine in a 40–60 mg/kg/d dose for an average of 100 days. This group showed significantly higher rates of improvement in the most common symptoms of FPIAP compared with the control group. In addition, the mesalamine group was less likely to need pharmacological treatment for gastroesophageal reflux disease and more likely to successfully transition to whole milk or soy milk after 1 year of age. In conclusion, using mesalamine can be a useful addition to the treatment of severe refractory cases of FPIAP.