Open AccessNeurological Complications Acquired During Pediatric Critical Illness: Exploratory “Mixed Graphical Modeling” Analysis Using Serum Biomarker Levels
Author(s) -
Vineet K. Raghu,
Christopher M. Horvat,
Patrick M. Kochanek,
Ericka L. Fink,
Robert S. B. Clark,
Panayiotis V. Benos,
Alicia K. Au
Publication year - 2021
Publication title -
pediatric critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.299
H-Index - 87
eISSN - 1947-3893
pISSN - 1529-7535
DOI - 10.1097/pcc.0000000000002776
Subject(s) - medicine , glial fibrillary acidic protein , biomarker , myelin basic protein , enolase , pediatrics , bioinformatics , central nervous system , biochemistry , chemistry , myelin , immunohistochemistry , biology
Neurologic complications, consisting of the acute development of a neurologic disorder, that is, not present at admission but develops during the course of illness, can be difficult to detect in the PICU due to sedation, neuromuscular blockade, and young age. We evaluated the direct relationships of serum biomarkers and clinical variables to the development of neurologic complications. Analysis was performed using mixed graphical models, a machine learning approach that allows inference of cause-effect associations from continuous and discrete data.