Open AccessPopulation Pharmacokinetics of IV Phenobarbital in Neonates After Congenital Heart Surgery
Author(s) -
Céline Thibault,
Shavonne L. Massey,
Maryam Y. Naim,
Nicholas S. Abend,
Athena F. Zuppa
Publication year - 2020
Publication title -
pediatric critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.299
H-Index - 87
eISSN - 1947-3893
pISSN - 1529-7535
DOI - 10.1097/pcc.0000000000002341
Subject(s) - extracorporeal membrane oxygenation , medicine , pharmacokinetics , volume of distribution , population , loading dose , phenobarbital , anesthesia , maintenance dose , dosing , albumin , environmental health
To develop a population pharmacokinetic model for IV phenobarbital in neonates following cardiac surgery and perform simulations to identify optimal dosing regimens.