Open AccessThe Endothelial Glycocalyx: A Fundamental Determinant of Vascular Permeability in Sepsis
Author(s) -
Jaime FernándezSarmiento,
Lina María Salazar-Peláez,
Joseph A. Carcillo
Publication year - 2020
Publication title -
pediatric critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.299
H-Index - 87
eISSN - 1947-3893
pISSN - 1529-7535
DOI - 10.1097/pcc.0000000000002266
Subject(s) - glycocalyx , vascular permeability , sepsis , medicine , microcirculation , septic shock , endothelium , edema , permeability (electromagnetism) , cardiology , immunology , biology , biochemistry , membrane
Sepsis is a significant cause of morbidity and mortality. Children with sepsis often have alterations in microcirculation and vascular permeability. Our objective is current evidence regarding the role of the endothelial glycocalyx as a determinant of capillary leakage in these patients.