Open AccessEndothelial-Dependent Vasomotor Dysfunction in Infants After Cardiopulmonary Bypass
Author(s) -
Luke T Krispinsky,
Ryan J. Stark,
David Parra,
Liming Luan,
David P. Bichell,
John B. Pietsch,
Fred S. Lamb
Publication year - 2020
Publication title -
pediatric critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.299
H-Index - 87
eISSN - 1947-3893
pISSN - 1529-7535
DOI - 10.1097/pcc.0000000000002049
Subject(s) - medicine , cardiopulmonary bypass , endothelial dysfunction , cardiology , vasodilation , vasomotor , anesthesia , sodium nitroprusside , perfusion , endothelium , nitric oxide
Cardiopulmonary bypass-induced endothelial dysfunction has been inferred by changes in pulmonary vascular resistance, alterations in circulating biomarkers, and postoperative capillary leak. Endothelial-dependent vasomotor dysfunction of the systemic vasculature has never been quantified in this setting. The objective of the present study was to quantify acute effects of cardiopulmonary bypass on endothelial vasomotor control and attempt to correlate these effects with postoperative cytokines, tissue edema, and clinical outcomes in infants.