Open AccessHepatobiliary Dysfunction and Disseminated Intravascular Coagulation Increase Risk of Mortality in Pediatric Hemophagocytic Lymphohistiocytosis*
Author(s) -
Joanne Goldman,
Moreshwar S. Desai,
Kenneth L. McClain,
M. Hossein Tcharmtchi,
Curtis Kennedy,
Kathleen Thompson,
Fong Lam,
Dalia Bashir,
Iván K. Chinn,
Baruch Goldberg,
Carl E. Allen,
Trung C. Nguyen
Publication year - 2018
Publication title -
pediatric critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.299
H-Index - 87
eISSN - 1947-3893
pISSN - 1529-7535
DOI - 10.1097/pcc.0000000000001684
Subject(s) - hemophagocytic lymphohistiocytosis , medicine , disseminated intravascular coagulation , coagulopathy , hemophagocytosis , retrospective cohort study , univariate analysis , population , gastroenterology , pediatrics , bone marrow , multivariate analysis , disease , environmental health , pancytopenia
Hemophagocytic lymphohistiocytosis poses significant challenges due to limited tools to guide clinical decisions in a population at high risk of death. We sought to assess whether disseminated intravascular coagulation and hepatobiliary dysfunction, significant comorbidities seen in critical care settings, would identify hemophagocytic lymphohistiocytosis patients with increased risk of mortality.