Open AccessHypofibrinogenemia Is Associated With Poor Outcome and Secondary Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome in Pediatric Severe Sepsis*
Author(s) -
Jessica Signoff,
Julie C. Fitzgerald,
David T. Teachey,
Fran Balamuth,
Scott L. Weiss
Publication year - 2018
Publication title -
pediatric critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.299
H-Index - 87
eISSN - 1947-3893
pISSN - 1529-7535
DOI - 10.1097/pcc.0000000000001507
Subject(s) - hypofibrinogenemia , medicine , hemophagocytic lymphohistiocytosis , macrophage activation syndrome , sepsis , retrospective cohort study , systemic inflammatory response syndrome , pediatrics , immunology , fibrinogen , disease
Some children with sepsis exhibit a sustained hyperinflammatory response that can trigger secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome. Although hypofibrinogenemia is a shared feature of sepsis and hemophagocytic lymphohistiocytosis, there are no data about fibrinogen as a biomarker to identify children with sepsis/secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome overlap. We hypothesized that hypofibrinogenemia is associated with poor outcomes and secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome and has utility as a screening biomarker for this sepsis phenotype.