Open AccessA Comprehensive Review of Ovarian Serous Carcinoma
Author(s) -
Yuichiro Hatano,
Kayoko Hatano,
Maho Tamada,
Ken Ichirou Morishige,
Hiroyuki Tomita,
Hiroyuki Yanai,
Akira Hara
Publication year - 2019
Publication title -
advances in anatomic pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.606
H-Index - 76
eISSN - 1533-4031
pISSN - 1072-4109
DOI - 10.1097/pap.0000000000000243
Subject(s) - serous fluid , serous carcinoma , ovarian carcinoma , medicine , malignancy , pathology , immunophenotyping , cystadenocarcinoma , carcinoma , oncology , ovarian cancer , cancer , immunology , flow cytometry
Although ovarian serous carcinoma is a well-studied human gynecologic malignancy, this high-grade tumor remains fatal. The main purpose of this review is to summarize the accumulated evidence on serous malignant tumors and to clarify the unresolved issues. We discuss the 8 dichotomies of serous carcinoma: high grade versus low grade, ovarian versus extraovarian primary, extrauterine versus uterine primary, sporadic versus hereditary, orthodox versus alternative histology, p53 overexpression versus complete absence of immunophenotype, TP53-mutated versus intact precursor, and therapy responsive versus refractory. In addition, we summarize the molecular classification of high-grade serous carcinoma. This review would lead readers to rapid and parallel developments in understanding high-grade serous carcinoma.