Open AccessExpression of Indoleamine 2, 3-dioxygenase 1 (IDO1) and Tryptophanyl-tRNA Synthetase (WARS) in Gastric Cancer Molecular Subtypes
Author(s) -
Shaolei Lu,
Li Juan Wang,
Kara Lombardo,
Yoonjin Kwak,
Woo Ho Kim,
Murray B. Resnick
Publication year - 2020
Publication title -
applied immunohistochemistry and molecular morphology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.868
H-Index - 60
eISSN - 1541-2016
pISSN - 1533-4058
DOI - 10.1097/pai.0000000000000761
Subject(s) - tissue microarray , microsatellite instability , indoleamine 2,3 dioxygenase , cancer research , biology , context (archaeology) , immunohistochemistry , cancer , immune system , gene , immunology , microsatellite , genetics , paleontology , tryptophan , allele , amino acid
Developments in genomic pathology have led to novel molecular classification schemes in gastric cancers. Two of these new subtypes, Epstein-Barr virus (EBV)-associated and microsatellite instability-high (MSI-H), are associated with a dominant T-cell-mediated immune response. The roles of the immune modulators, indoleamine 2, 3-dioxygenase 1 (IDO1) and tryptophanyl-tRNA synthetase (WARS), have not been investigated in the context of this classification.