Open AccessImpact of Low Humidity on Damage-associated Molecular Patterns at the Ocular Surface during Dry Eye Disease
Author(s) -
Alyce Danielle Alven,
Carolina Lema,
Rachel L. Redfern
Publication year - 2021
Publication title -
optometry and vision science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 97
eISSN - 1538-9235
pISSN - 1040-5488
DOI - 10.1097/opx.0000000000001802
Subject(s) - tears , pathogenesis , conjunctiva , inflammation , medicine , heat shock protein , matrix metalloproteinase , immunology , interleukin , pathology , cytokine , ophthalmology , biology , biochemistry , gene
Dry eye is one of the leading causes for individuals to seek eye care, whereas the pathogenesis is poorly understood. One mechanism in which dry eye inflammation may ensue is by the release of damage-associated molecular patterns (DAMPs) by damaged cells to stimulate the production of cytokines and matrix metalloproteinases. Examining DAMP levels on the ocular surface during dry eye disease (DED) will increase our understanding of their potential involvement in the pathogenesis of DED.