Open AccessNitric Oxide Synthase Inhibitors Prevent the Growth-Inhibiting Effects of Quinpirole
Author(s) -
Debora L. Nickla,
Laimeng Lee,
Kristen Totonelly
Publication year - 2013
Publication title -
optometry and vision science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 97
eISSN - 1538-9235
pISSN - 1040-5488
DOI - 10.1097/opx.0000000000000041
Subject(s) - quinpirole , dopamine agonist , agonist , dopamine , chemistry , endocrinology , ophthalmology , medicine , dopamine receptor d2 , receptor , dopaminergic
Both dopamine and nitric oxide (NO) have been implicated in the signal cascade mediating ocular growth inhibition. If both are part of the same pathway, which precedes the other? We tested the hypothesis that dopamine acts upstream of NO, by using two NOS inhibitors in combination with the dopamine agonist quinpirole, and measured the effects on ocular growth rate.