Open AccessAssessing Uncertainty in an Anatomical Site-Specific Gonorrhea Transmission Model of Men Who Have Sex With Men
Author(s) -
Ian H. Spicknall,
Kenneth H. Mayer,
Sevgi O. Aral,
Ethan Romero-Severson
Publication year - 2019
Publication title -
sexually transmitted diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.507
H-Index - 105
eISSN - 1537-4521
pISSN - 0148-5717
DOI - 10.1097/olq.0000000000000953
Subject(s) - gonorrhea , transmission (telecommunications) , rectum , medicine , urethra , men who have sex with men , urology , surgery , syphilis , immunology , human immunodeficiency virus (hiv) , computer science , telecommunications
Increased gonorrhea detection highlights the need for additional prevention efforts. Gonorrhea may only be acquired when there is contact between infected and uninfected anatomical sites. With 3 sites of infection, this leads to 7 plausible routes of men who have sex with men (MSM) transmission: urethra-to-rectum, rectum-to-urethra, urethra-to-oropharynx, rectum-to-oropharynx, oropharynx-to-urethra, oropharynx-to-rectum, and oropharynx-to-oropharynx. We characterize the uncertainty and potential importance of transmission from each anatomical site using a deterministic compartmental mathematical model.