Open AccessAntibiotic resistance: still a cause of concern?
Author(s) -
Malcolm R. DeBaun,
Cara Lai,
Mark Sanchez,
Michael Chen,
L. Henry Goodnough,
Amy Chang,
Julius A. Bishop,
Michael J. Gardner
Publication year - 2021
Publication title -
ota international
Language(s) - English
Resource type - Journals
ISSN - 2574-2167
DOI - 10.1097/oi9.0000000000000104
Subject(s) - antibiotics , antibiotic resistance , intensive care medicine , medicine , resistance (ecology) , drug resistance , public health , biology , microbiology and biotechnology , nursing , ecology
Antibiotic resistance remains a global public health concern with significant patient morbidity and tremendous associated health care costs. Drivers of antibiotic resistance are multifaceted and differ between developing and developed countries. Under evolutionary pressure, microbes acquire antibiotic tolerance through a variety of mechanisms at the cellular level. Patients after orthopaedic trauma are vulnerable to drug-resistant pathogens, particularly after open fractures. Traumatologists practicing appropriate antibiotic prophylaxis and treatment regimens mitigate infection and propagation of antibiotic resistance.