Open AccessAssociation Analysis Between HLA-DQA1 Loci and Neuromyelitis Optica Spectrum Disorder in a Han Chinese Population
Author(s) -
Lili Zhou,
Zelai He,
Lei Zhu,
Juanjuan Zhu,
JianHong Zhu,
Jialin Pan
Publication year - 2021
Publication title -
the neurologist/the neurologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 60
eISSN - 2331-2637
pISSN - 1074-7931
DOI - 10.1097/nrl.0000000000000394
Subject(s) - single nucleotide polymorphism , odds ratio , medicine , snp , genotype , logistic regression , genetic association , human leukocyte antigen , population , allele , genetics , immunology , gene , biology , antigen , environmental health
Genome-wide association studies for neuromyelitis optica spectrum disorder (NMOSD) have established an association between HLA-DQ alpha 1 (DQA1) and risk for NMOSD. Though ethnicity is generally considered a major influencing factor in genetic analyses, little is known regarding the association of HLA-DQA1 polymorphisms with NMOSD in the Han population, especially the single-nucleotide polymorphisms (SNPs) at HLA-DQA1 .