Open AccessA Case of Possible Chronic Traumatic Encephalopathy and Alzheimer’s Disease in an Ex-Football Player
Author(s) -
Arman Fesharaki-Zadeh
Publication year - 2021
Publication title -
the neurologist/the neurologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 60
eISSN - 2331-2637
pISSN - 1074-7931
DOI - 10.1097/nrl.0000000000000391
Subject(s) - chronic traumatic encephalopathy , medicine , dementia , neuroimaging , concussion , traumatic brain injury , head trauma , disease , primary progressive aphasia , psychiatry , frontotemporal dementia , poison control , pathology , surgery , injury prevention , environmental health
Chronic traumatic encephalopathy (CTE) is a debilitating neurodegenerative disease, which is often the sequelae of repetitive head trauma. Although the definitive diagnosis of CTE is made postmortem, there are proposed clinical algorithms aimed at identifying characteristic features of CTE, based on a combination of clinical history, serum, cerebrospinal fluid and neuroimaging biomarkers. There are promising new advances in positron emission tomography neuroimaging, including tau specific ligands, which will potentially provide a robust assessment as well as an exploratory tool of the disease semiology and progression.