Open AccessCase Series: Development of Polyps as a Late Effect After Total Body Irradiation-based Hematopoietic Cell Transplantation in Children With High-risk Leukemia
Author(s) -
Benjamin Knight,
Lynnette Anderson,
Diana G. Lerner,
Rachel Phelan,
Monica S. Thakar
Publication year - 2021
Publication title -
journal of pediatric hematology/oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.388
H-Index - 78
eISSN - 1536-3678
pISSN - 1077-4114
DOI - 10.1097/mph.0000000000002152
Subject(s) - medicine , total body irradiation , gastrointestinal tract , hematopoietic stem cell transplantation , leukemia , transplantation , hematopoietic cell , survivorship curve , parenteral nutrition , bone marrow transplantation , pediatrics , oncology , haematopoiesis , gastroenterology , stem cell , cancer , chemotherapy , biology , genetics , cyclophosphamide
Advancements in hematopoietic cell transplantation (HCT) have led to increased survivorship rates in many childhood diseases. However, this growing group of long-term survivors face a myriad of late effects. There are currently limited guidelines for surveillance of gastrointestinal polyps for pediatric transplant patients. Here we describe 5 patients undergoing HCT with total body irradiation-based conditioning regimens for leukemia who developed symptomatic polyps a median of 4.5 (range: 0.75 to 5.75) years after HCT. Because of limited surveillance guidelines in children, we conclude that the development of new or progressive symptoms related to the gastrointestinal tract deserves prompt recognition and evaluation.