Open AccessNUT Carcinoma Without Upfront Surgical Resection: A Case Report
Author(s) -
Rachel Leeman,
Kerice Pinkney,
Julie A. Bradley,
R T Alba Ruíz,
Steven G. DuBois,
Christopher A. French,
Matteo Trucco
Publication year - 2020
Publication title -
journal of pediatric hematology/oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.388
H-Index - 78
eISSN - 1536-3678
pISSN - 1077-4114
DOI - 10.1097/mph.0000000000001865
Subject(s) - medicine , chemotherapy , surgery , carcinoma , surgical resection , radiation therapy , sarcoma , resection , multimodal therapy , radiology , pathology
Nuclear protein in testis carcinoma is a rare and highly aggressive carcinoma associated with a 70% mortality rate 1 year from diagnosis and a median survival of only 6.5 months. No established treatment protocol exists, although some success has been achieved using a multimodal approach including early surgical resection and adjuvant chemotherapy and radiation. Prior studies have not demonstrated successful treatment in the absence of upfront surgical resection. We describe the first reported case of a patient with unresectable nuclear protein in testis carcinoma treated successfully with definitive chemotherapy using the Scandinavian Sarcoma Group IX Protocol and concurrent radiation therapy, but without surgical resection.