Open AccessHemophagocytic Lymphohistiocytosis in Langerhans Cell Histiocytosis: A Case Report and Review of the Literature
Author(s) -
Ashley R. Hinson,
Niraj Patel,
Joel A. Kaplan
Publication year - 2019
Publication title -
journal of pediatric hematology/oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.388
H-Index - 78
eISSN - 1536-3678
pISSN - 1077-4114
DOI - 10.1097/mph.0000000000001652
Subject(s) - langerhans cell histiocytosis , hemophagocytic lymphohistiocytosis , histiocytosis , medicine , histiocyte , presentation (obstetrics) , toddler , pediatrics , dermatology , pathology , psychology , surgery , disease , developmental psychology
A toddler undergoing treatment for refractory Langerhans cell histiocytosis (LCH) developed concurrent hemophagocytic lymphohistiocytosis (HLH). These are thought to be distinct histiocytic disorders, with different pathophysiologies, diagnostic criteria, and treatments. HLH in a patient with LCH is thought to be quite rare. In this report, we review the presentation of our patient, as well as review the existing literature of other pediatric patients who have been diagnosed with both LCH and HLH.