Open AccessQT Interval Prolongation in the Pediatric Oncologic Population on Methadone
Author(s) -
Jenna A Piccininni,
James S. Killinger,
Hoda T. Hammad,
Linda M. Gerber,
Jeffrey D. Dayton
Publication year - 2020
Publication title -
journal of pediatric hematology/oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.388
H-Index - 78
eISSN - 1536-3678
pISSN - 1077-4114
DOI - 10.1097/mph.0000000000001444
Subject(s) - medicine , qt interval , methadone , prolongation , population , anesthesia , retrospective cohort study , confidence interval , long qt syndrome , pediatrics , environmental health
Studies have been conducted on adults prescribed with methadone to determine the necessary frequency of QTc monitoring but no consensus has been reached and no similar research has been conducted in the pediatric population. The objective of this retrospective study was to determine the occurrence rate of QTc interval prolongation associated with methadone use in a pediatric oncologic population. In total, 18% of patients developed QTc interval prolongation. These patients had longer baseline QTc intervals and were on more QTc interval-prolonging medications. Our data suggest that these variables may be able to risk stratify patients who require more frequent monitoring.