Open AccessImmunogenicity of Hepatitis A Vaccine in Children With Celiac Disease
Author(s) -
Sari Sinan,
Dalgic Buket,
Basturk Bilkay,
Gonen Sevim,
Soylemezoglu Oguz
Publication year - 2011
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 131
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/mpg.0b013e318223b3ed
Subject(s) - seroconversion , medicine , immunogenicity , immunology , hepatitis a vaccine , titer , hepatitis a , virology , human leukocyte antigen , antigen , antibody titer , hepatitis , immune system , antibody
Objectives: The response to hepatitis A vaccine has not been studied in children with celiac disease (CD). The aim of the present study was to evaluate the immunogenicity of an inactivated hepatitis A virus (HAV) vaccine and the effect of the human leukocyte antigen (HLA) type on immunogenicity in children with CD. Patients and Methods: Thirty‐three patients with CD and 62 healthy controls were enrolled in the study. Inactivated HAV vaccine (Havrix; GlaxoSmithKline Biologicals, Rixensart, Belgium) containing 720 enzyme‐linked immunosorbent assay units of alum‐adsorbed hepatitis A antigen was administered intramuscularly in a 2‐dose schedule at 0 and 6 months. Seroconversion rates and antibody titers of HAV were measured at 1 and 7 months. Results: At 1 month, seroconversion rates were 78.8% and 77.4% and geometric mean titers were 50.7 and 49.9 mIU/mL in the CD and control groups, respectively ( P > 0.05). At 7 months, seroconversion rates were 97% and 98.4% and geometric mean titers were 138.5 and 133 mIU/mL in the CD and control groups, respectively ( P > 0.05). The most frequent HLA types were HLA‐DQ2, ‐DR3, and ‐DR7 alleles in patients with CD and HLA‐DQ3, ‐DQ6, ‐DR11, and ‐DR14 in the controls. There was no association between HLA alleles and antibody titers of hepatitis A vaccine. Conclusion: Children with CD have a good immune response to hepatitis A vaccine, similar to healthy controls.