Open AccessFecal Calprotectin: Cutoff Values for Identifying Intestinal Distress in Preterm Infants
Author(s) -
Campeotto Florence,
Baldassarre Mariella,
Butel MarieJosé,
Viallon Vivian,
Nganzali Flore,
Soulaines Pascale,
Kalach Nicolas,
Lapillonne Alexandre,
Laforgia Nicola,
Moriette Guy,
Dupont Christophe,
Kapel Nathalie
Publication year - 2009
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 131
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/mpg.0b013e318186c4a6
Subject(s) - medicine , cutoff , calprotectin , gastroenterology , feces , gestational age , enteropathy , receiver operating characteristic , reference range , pediatrics , pregnancy , inflammatory bowel disease , paleontology , physics , genetics , disease , quantum mechanics , biology
This study aimed to determine cutoff levels for fecal calprotectin as a marker of intestinal distress in preterm neonates. A total of 126 infants born at a median gestational age of 33 weeks (range 25.7–35 weeks) were enrolled. Samples (n = 312) were collected weekly from the end of the first week of life until the end of the first month and if any gastrointestinal event occurred. Receiver operating characteristic curves analysis gave cutoff values of 363 μg/g (sensitivity 0.65, specificity 0.82) and 636 μg/g (sensitivity 0.72, specificity 0.95) for the development of mild or severe enteropathy.