Open AccessDistress in Infants and Young Children
Author(s) -
Salvatore Silvia,
Pagliarin Federica,
Huysentruyt Koen,
Bosco Annalisa,
Fumagalli Letizia,
Van De Maele Kristel,
Agosti Massimo,
Vandenplas Yvan
Publication year - 2020
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 131
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/mpg.0000000000002841
Subject(s) - flacc scale , medicine , distress , esophageal ph monitoring , reflux , respiratory distress , pediatrics , gastroenterology , anesthesia , disease , randomized controlled trial , gerd , clinical psychology
Objective: The role of gastroesophageal reflux (GER) causing distress in infants is controversial but acid inhibitors are often empirically prescribed. We evaluated the relation between distress assessed by the Face, Legs, Activity, Cry, Consolability (FLACC) scale and GER in infants. Methods: We analyzed multiple intraluminal impedance‐pH (MII‐pH) monitoring tracings of infants with persistent unexplained fussiness or distress. Symptoms occurring during investigation were scored by parents using the FLACC scale and were grouped as “distress” episodes. Results: We recruited 62 children (ages 15 days to 23 months, median age 3.5 months). During MII‐pH, 452 episodes of distress were registered: 217 (48%) were temporally associated with GER and 235 (52%) were not, with no difference in the median value of FLACC between the 2 groups. Infants with abnormal acid exposure index had a significantly lower FLACC compared with the group with acid reflux index <7% ( P < 0.001). When associated with symptoms, GER occurred significantly more often before than simultaneously or after an episode of distress ( P = 0.001). Age, proximal extension, and duration of GER did not correlate with FLACC scores. Episodes of distress associated with nonacid reflux presented a significant higher FLACC compared with the ones with acid content (FLACC 6 vs 5, P = 0.011). In infants, episodes of distress do not significantly correlate with GER. Conclusions: No difference in infant distress was noted between proximal and distal GER. Non‐acid reflux is perceived at least as painful than acid GER. Our results stress that acid inhibitors should not be started in infants presenting distress unless a clear association with acid GER is demonstrated.