Open AccessA Micro‐longitudinal Approach to Measuring Medication Adherence in Pediatric Inflammatory Bowel Diseases
Author(s) -
Plevinsky Jill M.,
Denson Lee A.,
Hellmann Jenny,
Minar Phillip,
Rosen Michael J.,
Hommel Kevin A.
Publication year - 2020
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/mpg.0000000000002778
Subject(s) - medicine , pill , inflammatory bowel diseases , inflammatory bowel disease , medication adherence , regimen , gold standard (test) , physical therapy , pediatrics , pharmacology , disease
Measuring medication adherence in pediatric inflammatory bowel diseases (IBD) is challenging because of complexities in personalized treatment regimens and increased use of biologic mono‐ and combination therapy. Objective measurement of adherence via electronic monitoring is the gold standard; however, it is not useful for daily monitoring when multiple medication formulations (eg, pills, injections, infusions) as well as vitamins/supplements are prescribed. Although validated subjective measures are available, they are not designed for daily use and do not capture day‐to‐day variation in adherence. In the following article, a new approach to measuring adherence regardless of a patient's specific medication regimen is presented. Utilizing a micro‐longitudinal design, 30 days of daily self‐reported medication adherence data was collected from youth with IBD via text message. Results reflect mean adherence rates from studies utilizing pill counts and electronic monitoring, suggesting promise for the use of self‐reported daily diaries to assess medication adherence in pediatric IBD.