Open AccessUnintentional Manganese Delivery in Neonatal Parenteral Nutrition
Author(s) -
Sauberan Jason B.,
Katheria Anup C.
Publication year - 2020
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - Uncategorized
Resource type - Journals
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/mpg.0000000000002714
Subject(s) - medicine , manganese , trace element , neurotoxicity , inductively coupled plasma mass spectrometry , parenteral nutrition , contamination , ingredient , infant formula , mass spectrometry , nuclear chemistry , radiochemistry , pediatrics , chromatography , toxicity , metallurgy , chemistry , pathology , biology , materials science , ecology
Iatrogenic manganese (Mn) neurotoxicity is a safety concern in neonates receiving parenteral nutrition (PN). Prior studies suggest Mn contamination of PN ingredients represents an unintended source of Mn delivery. In order to determine the relative contribution of unsourced Mn to total Mn exposure in neonatal PN, this study measured Mn concentrations in neonatal PN solutions using inductively coupled plasma mass spectrometry. Solutions prepared using a standard fixed dose neonatal multiple trace element product were compared with test solutions prepared using individual trace element ingredients not including Mn. The standard solutions (n = 6) contained a mean (SD) Mn concentration of 56.63 μg/L (0.94), compared with 6.04 μg/L (0.39) in the test solutions without added Mn (n = 6). This study suggests that neonatal PN contains significant quantities of Mn not intentionally added during PN preparation. Further studies are needed to identify individual ingredient sources of unintentional Mn, and the feasibility of Mn omission strategies.