Open AccessVery Low Birth Weight Preterm Infants have Decreased Celiac Disease Autoimmunity During Childhood and Adolescence
Author(s) -
Ben Tov Amir,
Cohen Shlomi,
Shamir Raanan,
Chodick Gabriel,
MelzerCohen Cheli,
Shalev Varda,
Fayngor Rochelle,
Weintraub Yael,
YerushalmyFeler Anat,
Kuint Jacob
Publication year - 2020
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 131
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/mpg.0000000000002624
Subject(s) - medicine , odds ratio , low birth weight , pediatrics , confidence interval , birth weight , retrospective cohort study , premature birth , disease , pregnancy , gestational age , genetics , biology
Little is known about the effect of prematurity on later development of celiac disease (CD). We conducted a retrospective analysis of real‐world data examining the association between very low birth weight (VLBW) prematurity and later development of CD autoimmunity (CDA) in 3580 infants born between years 2000 and 2012 and their matched controls. At a median of 12 years, VLBW prematurity was negatively associated with later development of CDA with a cumulative prevalence of 5.9 per 1000 versus 10.3 per 1000 ( P = 0.02), though more former VLBW premature infants were ever tested for CDA (48.5% vs 37.4%, P < 0.001). The odds ratio for developing CDA among children born preterm at VLBW was 0.57 (95% confidence interval (CI) 0.35–0.92) as compared with matched controls. There was no difference in clinical characteristics of CDA between both groups. In conclusion, VLBW preterm infants present a decreased risk for the development of CDA during childhood and adolescence.