Open AccessTrough Levels of Infliximab at Week 6 Are Predictive of Remission at Week 14 in Pediatric Crohn's Disease
Author(s) -
Courbette Olivier,
Aupiais Camille,
Viala Jérôme,
Hugot JeanPierre,
Roblin Xavier,
Candon Sophie,
Louveau Baptiste,
Chatenoud Lucienne,
MartinezVinson Christine
Publication year - 2020
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 131
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/mpg.0000000000002536
Subject(s) - medicine , infliximab , crohn's disease , retrospective cohort study , logistic regression , trough level , medical record , gastroenterology , disease , surgery , transplantation , tacrolimus
Objective: Infliximab (IFX) is a frequent therapeutic option for Crohn disease (CD) patients. Early detection of responders to IFX is critical for the management of CD in order to avoid long‐term exposure to the drug without benefit. This retrospective study aimed at analysing which early parameters recorded during the induction period are able to predict response to IFX during the maintenance period in pediatric CD. Patients and Methods: Medical records of all CD patients ages from 2 to 18 years who received IFX at a tertiary IBD center were retrospectively analyzed. Children were classified in 3 groups according to their response at week 14 (W14) (1) remission, (2) clinical response or (3), no response. The factors recorded at W0, W2, and W6, which were associated with remission at W14 were analyzed using a logistic regression. Results: Among the 111 patients included, 74.8% patients were responders to IFX at W14, including 38.7% in clinical remission and 36% with partial clinical response. Clinical remission at W14 was associated with normal growth ( P < 0.01), and normal albuminemia ( P = 0.01) at baseline, It was also associated with trough levels to IFX >8.3 μg/ml at week 6 ( P < 0.01). Conclusion: Trough levels to IFX >8.3 μg/ml at week 6 are predictive of remission at W14 for luminal disease.