Open AccessPredictors of Long‐term Clinical and Endoscopic Remission in Children With Crohn Disease Treated With Infliximab
Author(s) -
D'Arcangelo Giulia,
Oliva Salvatore,
Dilillo Anna,
Viola Franca,
Civitelli Fortunata,
Isoldi Sara,
Cucchiara Salvatore,
Aloi Marina
Publication year - 2019
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 131
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/mpg.0000000000002262
Subject(s) - medicine , infliximab , crohn's disease , term (time) , disease , crohn disease , gastroenterology , surgery , pediatrics , physics , quantum mechanics
Objectives: We aimed to identify early noninvasive predictors of clinical and endoscopic remission in children with Crohn disease (CD) under infliximab (IFX). Methods: Prospective observational study conducted in children with moderate‐to‐severe CD starting IFX. All patients underwent weighted pediatric CD activity index (wPCDAI) assessment, C‐reactive protein and fecal calprotectin (FC) at week 0, 14, and 48. Endoscopy was performed at 0 and 48 weeks. The primary outcome was to determine the ability of 14‐week wPCDAI, C‐reactive protein, and FC to predict 1‐year steroid‐free clinical remission and mucosal healing. As a secondary outcome we evaluated their concordance with Simple Endoscopic Score for CD (SES‐CD) at week 48. Results: Forty‐one children were enrolled. At 1 year, 21 (51%) and 16 (39%) were in clinical and endoscopic remission. Only combined postinduction FC and wPCDAI were able to predict 1‐year clinical and endoscopic remission (hazard ratio 4.81 [95% confidence interval 1.76–20.45], P = 0.05 and hazard ratio 5.51 [95% confidence interval 1.83–26.9], P = 0.03). One‐year SES‐CD moderately correlated with FC ( r = 0.52; P = 0.001). The FC cut‐off value for mucosal healing was 120.5 μg/g (area under the curve 0.863, 83% sensitivity, 75.5% specificity; P = 0.005). The concordance between wPCDAI and SES‐CD was excellent and good for severe disease and remission ( k 0.87 and 0.76). Conclusions: Post induction FC combined with wPCDAI can predict 1‐year clinical and endoscopic response to IFX in pediatric CD. FC shows a moderate correlation with SES‐CD, whereas wPCDAI has a good concordance with endoscopic remission or severe disease, but not with mild and moderate disease.