Open AccessFood Protein‐induced Enterocolitis Syndrome
Author(s) -
Díaz Juan J.,
Espín Beatriz,
Segarra Oscar,
DomínguezOrtega Gloria,
BlascoAlonso Javier,
Cano Beatriz,
Rayo Ana,
Moreno Ana
Publication year - 2019
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 131
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/mpg.0000000000002169
Subject(s) - medicine , enterocolitis , vomiting , pediatrics , diarrhea , retrospective cohort study , lethargy , abdominal distension , epidemiology
Objective: The aim of the study was to describe clinical, epidemiological, and management characteristics of food protein‐induced enterocolitis syndrome (FPIES) cases in Spain. Patients and Methods: Multicenter observational retrospective study. FPIES cases diagnosed in specialized units in Spain over 12 months in 2017 (January–December) according to the recently published international diagnostic criteria were included. Results: One hundred twenty patients (53.3% boys) were included. The majority were acute cases (111) with mild‐to‐moderate severity (76.7%). Triggering foods were cow's milk (48/120), fish (38), egg (13), rice (12), and soy (1). The majority (84.2%) of the patients had FPIES to 1 food only. In addition to vomiting (100%), pallor (89.2%), and altered behavior (88.3%) were most frequently observed in acute forms. On the contrary, diarrhea (70%), abdominal distension (33.3%), and blood in stools (44.4%) were more frequently observed in chronic cases. Oral challenge was performed in 18.9% of the acute forms compared to 44.4% of the chronic forms. The most common treatment was intravenous fluids followed by ondansetron. Corticosteroids were used in 6 patients (5 with acute symptoms and 1 chronic). Seven patients were treated with antibiotics for suspicion of infection. Most cases of cow's milk FPIES were treated with extensively hydrolyzed formulas (69.8%). Conclusions: FPIES is not uncommon in our units. Unlike other published series, fish and egg are important triggers in our country. A greater knowledge and diffusion of the international consensus criteria will allow a better characterization of the cases and a standardization of their management.