Open AccessLow Insulin‐like Growth Factor‐1 Influences Fatigue and Quality of Life in Children With Inflammatory Bowel Disease
Author(s) -
Lucia Casadonte Chantal J.,
Brown Jeffrey,
Strople Jennifer,
Neighbors Katie,
Fei Lin,
Alonso Estella M.
Publication year - 2018
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 131
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/mpg.0000000000002057
Subject(s) - medicine , interquartile range , proinflammatory cytokine , inflammatory bowel disease , quartile , prospective cohort study , quality of life (healthcare) , gastroenterology , disease , inflammation , confidence interval , nursing
Objective: Fatigue is common among patients with inflammatory bowel disease (IBD). Proinflammatory cytokines are elevated in chronic inflammation and can induce “sickness behaviors,” such as fatigue. Chronic inflammatory states also lead to growth hormone resistance, demonstrated by low levels of insulin‐like growth factor (IGF‐1) and elevated growth hormone. This study evaluated the relationship between IGF‐1, proinflammatory cytokine levels, and fatigue in patients with IBD. Methods: In this prospective study children with IBD, ages 10 to 16 years, were recruited from a subspecialty ambulatory clinic. Participants and their parents completed age‐appropriate generic and disease‐specific health‐related quality of life (HRQOL) instruments. Serum samples obtained at the same encounter were analyzed for Th17 cytokine and IGF‐1 levels. HRQOL scores were compared to a healthy sample and HRQOL scores and cytokine levels were compared by IGF‐1 z score quartiles. Results: A total of 67 patients with IBD were recruited, median age of 13.7 years (interquartile range, 11.7–15.3). Forty‐eight (72%) had inactive disease based on Physician Global Assessment. Patients with IBD reported lower generic HRQOL ( P = 0.0006) and more fatigue ( P = 0.0004) than a healthy sample. Patients with IGF‐1 z scores in the lowest quartile had significantly lower disease‐specific HRQOL ( P = 0.01) and more fatigue ( P = 0.02) than the remainder of the cohort. Serum interleukin (IL)‐10, IL‐17A, IL‐6, and interferon‐γ were significantly higher in patients with IBD with IGF‐1 z scores in the lowest quartile ( P < 0.05). Conclusions: Children with subclinical IBD experience more fatigue and lower generic HRQOL than healthy children. Lower IGF‐1 z scores are associated with more fatigue, and this relationship may be mediated through proinflammatory cytokines.