Open AccessIntestinal Microbial and Metabolic Alterations Following Successful Fecal Microbiota Transplant for D‐Lactic Acidosis
Author(s) -
BulikSullivan Emily C.,
Roy Sayanty,
Elliott Ryan J.,
Kassam Zain,
Lichtman Steven N.,
Carroll Ian M.,
Gulati Ajay S.
Publication year - 2018
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 131
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/mpg.0000000000002043
Subject(s) - medicine , lactic acidosis , fecal bacteriotherapy , metabolic disorder , metabolic acidosis , lactic acid , acidosis , feces , short bowel syndrome , gastroenterology , pathogenesis , enterocolitis , transplantation , clostridium difficile , microbiology and biotechnology , bacteria , biology , parenteral nutrition , antibiotics , genetics
Fecal microbiota transplantation (FMT) involves the transfer of stool from a healthy individual into the intestinal tract of a diseased recipient. Although used primarily for recurrent Clostridium difficile infection, FMT is increasingly being attempted as an experimental therapy for other illnesses, including metabolic disorders. D‐lactic acidosis (D‐LA) is a metabolic disorder that may occur in individuals with short bowel syndrome when lactate‐producing bacteria in the colon overproduce D‐lactate. This results in elevated systemic levels of D‐lactate, metabolic acidosis, and encephalopathy. In this study, we report the successful use of FMT for the treatment of recurrent D‐LA in a child who was unresponsive to conventional therapies. Importantly, we also present profiles of the enteric microbiota, as well as fecal D‐/L‐lactic acid metabolites, before and longitudinally after FMT. These data provide valuable insight into the putative mechanisms of D‐LA pathogenesis and its treatment.