Open AccessInduced Pluripotent Stem Cell‐Derived Hepatocytes and Precision Medicine in Human Liver Disease
Author(s) -
Kulkarni Sakil,
Rudnick David A.
Publication year - 2018
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/mpg.0000000000001948
Subject(s) - induced pluripotent stem cell , medicine , human liver , precision medicine , human induced pluripotent stem cells , liver disease , regenerative medicine , human disease , stem cell , disease , translational medicine , bioinformatics , computational biology , cancer research , microbiology and biotechnology , embryonic stem cell , pathology , biology , biochemistry , in vitro , gene
Liver‐like human cells can be generated from human skin by converting fibroblasts to “induced pluripotent stem cells” (iPSCs), then differentiating the iPSCs into “induced hepatocytes”. Although still primarily used as a research tool, emerging applications involving iPSC‐derived induced hepatocytes have exciting and provocative clinical and translational potential. This review provides a brief summary of the current status of this field and obstacles that must be overcome before this novel tool will enable precision medicine‐based approaches to human liver disease.