Open AccessPosttranslational Processing and Function of Mucosal Maltases
Author(s) -
Amiri Mahdi,
Naim Hassan Y.
Publication year - 2018
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/mpg.0000000000001826
Subject(s) - disaccharidase , sucrase , maltase , glycoprotein , medicine , biochemistry , enzyme , carbohydrate , intestinal mucosa , biology
ABSTRACT The final step of carbohydrate digestion in the intestine is performed by 2 major α‐glucosidases of the intestinal mucosa, sucrase‐isomaltase (SI) and maltase‐glucoamylase. Both of these enzymes are type II membrane glycoproteins, which share a significant level of homology in gene and protein structures and yet have differences in the posttranslational processing, substrate specificity and functional capacity. Insufficient activity of these disaccharidases particularly SI as a result of genetic mutations or secondary intestinal pathologies is associated with carbohydrate maldigestion and gastrointestinal intolerances. This review will discuss the maturation profiles of SI and maltase‐glucoamylase relative to their functional capacities and deficiencies.