Open AccessHigh Incidence of Proteinuria in Children With Chronic Intestinal Failure Under Long‐term Parenteral Nutrition
Author(s) -
Billing Heiko,
Traunspurger Anna,
Sturm Ekkehard,
Busch Andreas
Publication year - 2018
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/mpg.0000000000001814
Subject(s) - medicine , proteinuria , kidney disease , incidence (geometry) , parenteral nutrition , nephrocalcinosis , etiology , nephropathy , gastroenterology , renal function , urinary system , pediatrics , kidney , diabetes mellitus , endocrinology , optics , physics
Long‐term home parenteral nutrition (LTPN) in children with chronic intestinal failure (CIF) is associated with renal complications such as fluid and electrolyte imbalances, nephrocalcinosis, nephrolithiasis, and chronic kidney disease (CKD). The etiology of CIF‐associated nephropathy is multifactorial. The aim of this study was to evaluate renal involvement under LTPN. In this study, 50 patients with CIF, median age 4.2 years (1.4–9.3; 23 girls) were included. Kidney involvement was a frequent finding in this study. CKD was present in 30% of patients without correlation with LTPN duration. Glomerular proteinuria was found in the majority of patients (76%), an important long‐term risk factor for the progression of CKD. Increased urinary α‐1 microglobulin was significantly associated with duration (years) of LTPN and was increased in patients with CKD.