Open AccessValue of an Additional Review for Eosinophil Quantification in Esophageal Biopsies
Author(s) -
Stucke Emily M.,
Clarridge Katherine E.,
Collins Margaret H.,
Henderson Carol J.,
Martin Lisa J.,
Rothenberg Marc E.
Publication year - 2015
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 131
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/mpg.0000000000000740
Subject(s) - eosinophilic esophagitis , medicine , eosinophil , high power field , pathology , biopsy , esophagitis , gastroenterology , disease , reflux , immunohistochemistry , asthma
Eosinophilic esophagitis (EoE) requires a peak count of 15 eosinophils per high‐power field (hpf). Herein, the peak eosinophil count specified by a pathologist was compared with the second review of a research assistant. Of 477 biopsies, 106 had a peak count between 1 and 14 eosinophils/hpf cited in the pathology report, and 23/106 (22%) had ≥15 eosinophils/hpf on second review. The pathology report detected potential EoE with 99% specificity, but 80% sensitivity. As such, an additional review of esophageal biopsies yields higher eosinophil counts in ∼5% of cases. We propose that biopsies with a count between 1 and 14 eosinophils/hpf require further investigation because ∼22% may yield a potential EoE diagnosis.