Open AccessEfficacy of Fecal Microbiota Transplantation in 2 Children With Recurrent Clostridium difficile Infection and Its Impact on Their Growth and Gut Microbiome
Author(s) -
Walia Ritu,
Garg Shashank,
Song Yang,
Girotra Mohit,
Cuffari Carmen,
Fricke Wolfgang Florian,
Dutta Sudhir K.
Publication year - 2014
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 131
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/mpg.0000000000000495
Subject(s) - clostridium difficile , fecal bacteriotherapy , microbiome , medicine , feces , gut flora , transplantation , microbiology and biotechnology , bacteroides , immunology , antibiotics , bacteria , biology , bioinformatics , genetics
Fecal microbiota transplantation (FMT) is recognized as an alternative therapeutic modality for recurrent Clostridium difficile infection (RCDI); however, data on its efficacy in children are lacking, including its effect on their growth and fecal microbiota. We report on 2 young children (<3 years old) who failed available therapeutics for RCDI, but responded remarkably well to FMT. Besides resolution of clinical features of C difficile infection (CDI), FMT administration led to marked improvement in their growth, along with increased microbiota diversity, especially proportion of Bacteroides . Our 2 cases illustrate the efficacy of FMT in children with RCDI and its positive effect on their growth and gut microbiota.