Open AccessEarly‐Life Factors Associated With Pediatric Functional Constipation
Author(s) -
Turco Rossella,
Miele Erasmo,
Russo Marina,
Mastroianni Rossella,
Lavorgna Alessandra,
Paludetto Roberto,
Pensabene Licia,
Greco Luigi,
Campanozzi Angelo,
Borrelli Osvaldo,
Romano Claudio,
Chiaro Andrea,
Guariso Graziella,
Staiano Annamaria
Publication year - 2014
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 131
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/mpg.0000000000000209
Subject(s) - medicine , functional constipation , odds ratio , constipation , atopy , breast feeding , pediatrics , confidence interval , risk factor , prospective cohort study , breastfeeding , immunopathology
Objective: This multicenter prospective study aimed to establish possible risk factors for functional constipation (FC) in the first year of life. Methods: At the infant's age of 3, 6, and 12 months, parents of all included infants completed 2 questionnaires: one about the presence of FC and the other screened the possible risk factors for FC. Parents of 465 infants completed the questionnaires at 3 and 6 months and of 402 infants at 12 months of life. Results: According to the Rome III criteria, FC was found in 11.6% of the infants at 3 months, in 13.7% at 6 months, and in 10.7% at 12 months after birth. Family history of atopy was present in 38.8% and 45.3% of infants with constipation at 3 and 6 months ( P = 0.04 and P = 0.02, respectively), but no significant association was found at 12 months ( P = 0.80). Breast‐feeding was significantly related to a normal evacuation pattern at 3 months ( P = 0.05), but not at 6 and 12 months ( P = 0.12 and P = 0.9, respectively). Acetaminophen and female sex appeared to be risk factors for FC at 12 months. After the adjustment for all analyzed variables, FC in infants was significantly associated with the use of acetaminophen (odds ratio 6.98, 95% confidence interval 0.82–13.50). Conclusions: Our results confirmed that breast‐feeding is a protective factor for FC in the first 3 months of life and that the female sex is at risk to have FC. We found that the use of acetaminophen was associated with a higher incidence of FC in the first year of life.