Homeobox Gene CDX2 Inhibits Human Pancreatic Cancer Cell Proliferation by Down-Regulating Cyclin D1 Transcriptional Activity
Author(s) -
Kenji Takahashi,
Fuminori Hirano,
Kakuya Matsumoto,
Kazunobu Aso,
Masakazu Haneda
Publication year - 2008
Publication title -
pancreas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.061
H-Index - 104
eISSN - 1536-4828
pISSN - 0885-3177
DOI - 10.1097/mpa.0b013e31817fa2ba
Subject(s) - cdx2 , cyclin d1 , transfection , cancer research , cell growth , pancreatic cancer , cell cycle , biology , homeobox , cell culture , microbiology and biotechnology , transcription factor , cell , cancer , gene , biochemistry , genetics
Homeobox gene caudal related homeobox gene 2 (CDX2) is an intestine-specific tumor suppressor gene. This study is intended to investigate the effect of CDX2 expression on cell proliferation and cyclin D1 expression in pancreatic cancer cells.
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