Open AccessDirect Effects of Lipopolysaccharide on Human Pancreatic Cancer Cells
Author(s) -
Roxanne L. Massoumi,
Yaroslav Teper,
Soichiro Ako,
Linda Ye,
Elena Wang,
Oscar J. Hines,
Guido Eibl
Publication year - 2021
Publication title -
pancreas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.061
H-Index - 104
eISSN - 1536-4828
pISSN - 0885-3177
DOI - 10.1097/mpa.0000000000001790
Subject(s) - pi3k/akt/mtor pathway , protein kinase b , toll like receptor , cancer research , biology , blot , lipopolysaccharide , ribosomal protein s6 , signal transduction , cell culture , microbiology and biotechnology , receptor , p70 s6 kinase 1 , gene , endocrinology , innate immune system , biochemistry , genetics
Obesity, a risk factor for pancreatic adenocarcinoma (PDAC), is often accompanied by a systemic increase in lipopolysaccharide (LPS; metabolic endotoxemia), which is thought to mediate obesity-associated inflammation. However, the direct effects of LPS on PDAC cells are poorly understood.